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Depressed mood is familiar to everyone. In this small memo book, A. Dobrovich, a well-known scientist, author of many books and a psychiatrist with many years of practical experience, introduces the reader to depression as a disease, telling how it differs from the depression that is inevitable in the life of any person. It is important to recognize this disease in time and begin treatment, the task of which is to eliminate temporary malfunctions of the biochemical level that occur in the brain. Information about the nature of these problems and the means of their elimination is given in the appendix. At the same time, the main text of the memo is available to any reader and is aimed primarily at helping the sick person.